Van de Ven Brace Halts Everton's Run at Brand New Home Ground
The Dutch defender emerged as the first defender to net two goals in a Premier League match for Spurs since the Belgian defender in spring 2013.
At a glance
The Spurs defender nods into the net twice in opening period
Everton's defender has goal ruled after video check
Senegalese midfielder scores final goal in dying moments
This loss is Everton's first at Hill Dickinson Stadium
Micky van de Ven scored twice as Spurs extended their unbeaten run in away games in the top division and handed Everton their initial loss at their new home.
The Toffees were undefeated in their last five matches at their new ground at the dockside location, having left Goodison Park behind after 133 years at the end of last season.
But Tottenham's leader the Dutchman pounced on two occasions from corners in the first half to place their strong form at risk, and they were unable to mount a comeback before the midfielder - set up by ex-Everton forward the Brazilian - nodded in a final goal to seal the victory.
The Everton defender thought he had levelled the tally five minutes after Van de Ven's opener, directing a powerful header past the Spurs keeper from an set-piece.
Beto, in the meantime, failed to convert a number of opportunities, while the Italian goalkeeper made a series of excellent saves to guarantee Tottenham went five matches on the road without defeat in the English top flight.
But the VAR stepped in, advising the match official to check the score on the screen and the referee ruled that Jack Grealish and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
This victory elevates the manager's side up to third in the Premier League, five points off local foes and leaders the Gunners.
Everton remain 14th and are half a dozen points ahead of the drop zone.
Tottenham analysis: Van de Ven fulfils duties at each end of the field
After a uninspiring weekday performance in the Champions League against the French side, where they managed a mere two shots on goal, Frank chose the French striker up front instead of former Toffees player Richarlison.
The summer signing was unable to influence the game before being replaced for Richarlison after 60 minutes on the field, but it emerged he proved unnecessary in the final outcome.
Defender Van de Ven transformed into an offensive threat to be reckoned with.
Tottenham's first goal came from a well-worked set-piece play, with the midfielder heading the ball back across the face of goal for an free Van de Ven to head home.
And Ven de Ven - stepping up as skipper in the Argentine's unavailability - notched his next goal in first-half stoppage time as he rose above Jordan Pickford to head home.
The Dutchman was just as impressive in defensive duties, combining effectively with his defensive colleague as the pair handled excellently with the 34 crosses sent their way by the opposition.
Toffees breakdown: Everton missing striker's instinct
The club's new home had been a fortress, but it seems the freshness may have worn off somewhat and fans headed to the gates after Sarr's final goal for Tottenham.
The end in Everton's unbeaten home run won't be a massive concern for David Moyes, but their attacking woes are.
The forward and the other striker - the Everton's pair of recognised centre-forwards - had scored just one league goal combined before the weekend's match.
And they were failed to add to that poor record on a damp and dreary night on Merseyside.
The striker's form was epitomized when he chose to overhead kick a golden opportunity from near the goal, despite having space and time to readjust for a more conventional attempt that would have challenged the keeper.
The substitute, too, failed to make an impact after coming on for Beto in the 65th minute.
It wasn't for a lack of chance. Most of the home side's offensive moves came through Grealish and Ndiaye, who tirelessly whipped threatening crosses into the Spurs box.
Upcoming fixtures for these two sides?
Everton: The team head to the Stadium of Light in the top flight on Monday, 3 November at 20:00 GMT.
Tottenham: Spurs travel to Newcastle's ground on Wednesday, 29 October for their fourth-round League Cup tie against Newcastle.